The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host’s epithelial cell–cell junctions

The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host’s epithelial cell–cell junctions

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19), disrupts the alveolar epithelial barrier and exacerbates airway inflammation, leading to acute respiratory failure. The Envelope (E) protein is key to virulence, notably throug...

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Main Authors: Flavio Alvarez, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Batiste Boëda, Vincent Michel, Danielle Seilhean, Magali Tichit, David Hing, David Hardy, Etienne Kornobis, Hervé Bourhy, Nicolas Wolff, Célia Caillet-Saguy
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
SARS-CoV-2
E protein
PDZ binding motif
Tight junctions
Virulence
Epithelial barrier
Online Access:https://doi.org/10.1186/s11658-025-00758-y
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https://doi.org/10.1186/s11658-025-00758-y

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