Uncovering common transcriptional features shared by mature peripheral blood PMN-MDSCs and tumor-infiltrating neutrophils in humans

Uncovering common transcriptional features shared by mature peripheral blood PMN-MDSCs and tumor-infiltrating neutrophils in humans

Human polymorphonuclear-myeloid-derived suppressor cells (PMN-MDSCs) consist of circulating low-density neutrophils (LDNs) characterized by the ability to inhibit T-cell responses. In previous studies, we demonstrated that the mature fraction of PMN-MDSCs (i.e. mPMN-MDSCs) exerts more potent immunos...

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Bibliographic Details
Main Authors: Chiara Lattanzi, Francisco Bianchetto-Aguilera, Marta Donini, Francesca Pettinella, Elena Caveggion, Monica Castellucci, Sara Gasperini, Barbara Mariotti, Ilaria Signoretto, Maurizio Cantini, Sara Pilotto, Lorenzo Belluomini, Cristina Tecchio, Flavia Bazzoni, Sven Brandau, Nicola Tamassia, Marco A. Cassatella, Patrizia Scapini
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Neutrophils
PMN-MDSCs
G-CSF
TANs
scRNA-seq
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2521396
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2521396

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