Lysosphingolipids in ceramide-deficient skin lipid models

Lysosphingolipids in ceramide-deficient skin lipid models

Ceramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine-phosphorylcholine (SPC), and free fatty aci...

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Bibliographic Details
Main Authors: Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Lipid Research
Subjects:
skin barrier
permeability
ceramide
lysolipid
glucosylsphingosine
sphingosine-phosphorylcholine
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752400227X
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