Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems

Abstract Myosin motors are fundamental biological actuators that power diverse mechanical tasks in eukaryotic cells via ATP hydrolysis. Previous work has linked myosin’s velocity-dependent detachment rate to macroscopic scale muscle dynamics described by Hill’s model, yet its impact on energetic flo...

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Bibliographic Details
Main Authors: Jake McGrath, Brian Kent, Colin L. Johnson, José Alvarado
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08098-5
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