Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside
Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression of IDD is driven by excessive oxidative stress, inflammation, apoptosis, and fibrosis, which disrupt t...
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MDPI AG
2025-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/3/313 |
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| author | Yifan Ding Fan Li Yunyun Wang Weizhen Pan Xiangning Fu Songwei Tan |
| author_facet | Yifan Ding Fan Li Yunyun Wang Weizhen Pan Xiangning Fu Songwei Tan |
| author_sort | Yifan Ding |
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| description | Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression of IDD is driven by excessive oxidative stress, inflammation, apoptosis, and fibrosis, which disrupt the balance between anabolic and catabolic processes, leading to extracellular matrix (ECM) degradation and IDD. Current treatment options, such as conservative therapy and surgical intervention, are limited in halting the disease progression and often exacerbate degeneration in adjacent discs. This review highlights the challenges in treating IDD, particularly due to the limited drug delivery efficiency to the intervertebral disc (IVD). It explores the potential of nanobiomedicine and various nanomaterial-based delivery systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, and nanomaterial-composite hydrogels. These advanced delivery systems can enhance targeted drug delivery, improve local drug concentration, and sustain drug retention within the IVD, offering promising therapeutic strategies to address IDD. The review also examines the therapeutic effects of these nanomaterials on IDD, focusing on their impact on metabolism, inflammation, apoptosis, fibrosis, and stem cell migration and differentiation, aiming to provide innovative strategies for intervertebral disc regeneration. |
| format | Article |
| id | doaj-art-8c004976cb7145a590f366f483ddefb7 |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-8c004976cb7145a590f366f483ddefb72025-08-20T02:42:24ZengMDPI AGPharmaceutics1999-49232025-02-0117331310.3390/pharmaceutics17030313Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to BedsideYifan Ding0Fan Li1Yunyun Wang2Weizhen Pan3Xiangning Fu4Songwei Tan5Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Cardiology, the Fifth Hospital of Wuhan, Jianghan University, Wuhan 430030, ChinaSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaIntervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression of IDD is driven by excessive oxidative stress, inflammation, apoptosis, and fibrosis, which disrupt the balance between anabolic and catabolic processes, leading to extracellular matrix (ECM) degradation and IDD. Current treatment options, such as conservative therapy and surgical intervention, are limited in halting the disease progression and often exacerbate degeneration in adjacent discs. This review highlights the challenges in treating IDD, particularly due to the limited drug delivery efficiency to the intervertebral disc (IVD). It explores the potential of nanobiomedicine and various nanomaterial-based delivery systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, and nanomaterial-composite hydrogels. These advanced delivery systems can enhance targeted drug delivery, improve local drug concentration, and sustain drug retention within the IVD, offering promising therapeutic strategies to address IDD. The review also examines the therapeutic effects of these nanomaterials on IDD, focusing on their impact on metabolism, inflammation, apoptosis, fibrosis, and stem cell migration and differentiation, aiming to provide innovative strategies for intervertebral disc regeneration.https://www.mdpi.com/1999-4923/17/3/313intervertebral disc degenerationnanomedicinedrug deliveryinflammationregenerative medicine |
| spellingShingle | Yifan Ding Fan Li Yunyun Wang Weizhen Pan Xiangning Fu Songwei Tan Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside Pharmaceutics intervertebral disc degeneration nanomedicine drug delivery inflammation regenerative medicine |
| title | Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside |
| title_full | Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside |
| title_fullStr | Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside |
| title_full_unstemmed | Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside |
| title_short | Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside |
| title_sort | nanomedicine approaches for intervertebral disc regeneration from bench to bedside |
| topic | intervertebral disc degeneration nanomedicine drug delivery inflammation regenerative medicine |
| url | https://www.mdpi.com/1999-4923/17/3/313 |
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