Loss of Hoxa5 function affects Hox gene expression in different biological contexts

Loss of Hoxa5 function affects Hox gene expression in different biological contexts

Abstract Hoxa5 plays numerous roles in development, but its downstream molecular effects are mostly unknown. We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and muscu...

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Main Authors: Béatrice Frenette, Josselin Guéno, Nicolas Houde, Kim Landry-Truchon, Anthony Giguère, Theyjasvi Ashok, Abigail Ryckman, Brian R. Morton, Jennifer H. Mansfield, Lucie Jeannotte
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Hoxa5
Hox expression
Hoxa5 mutant mice
Chromatin landscape
Respiratory system
Musculoskeletal system
Online Access:https://doi.org/10.1038/s41598-024-81867-0
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https://doi.org/10.1038/s41598-024-81867-0

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