Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies

Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies

In search of novel antidiabetic agents, we synthesized a new series of chalcones with benzimidazole scaffolds by an efficient ‘one-pot’ nitro reductive cyclization method and evaluated their α-glucosidase and α-amylase inhibition studies. The ‘one-pot’ nitro reductive cyclization method offered a si...

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Bibliographic Details
Main Authors: Prashasthi V. Rai, Ramith Ramu, P. Akhileshwari, Sudharshan Prabhu, Nupura Manish Prabhune, P. V. Deepthi, P. T. Anjana, D. Ganavi, A. M. Vijesh, Khang Wen Goh, Mohammad Z. Ahmed, Vasantha Kumar
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
benzimidazoles
chalcones
crystal structure
α-glucosidase
α-amylase
docking studies
Online Access:https://www.mdpi.com/1420-3049/29/23/5599
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