Piericidin A aggravates Tau pathology in P301S transgenic mice.

Piericidin A aggravates Tau pathology in P301S transgenic mice.

<h4>Objective</h4>The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural c...

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Main Authors: Matthias Höllerhage, Roman Deck, Anderson De Andrade, Gesine Respondek, Hong Xu, Thomas W Rösler, Mohamed Salama, Thomas Carlsson, Elizabeth S Yamada, Seham A Gad El Hak, Michel Goedert, Wolfgang H Oertel, Günter U Höglinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0113557
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https://doi.org/10.1371/journal.pone.0113557

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