Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial

Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial

BackgroundMicrobiome manipulation research is focused on developing techniques to modify the gut microbiome and augment responses to immune checkpoint inhibitors (ICI). Fecal microbiota transplantation (FMT) represents a potential strategy to overcome primary or acquired resistance to ICI. 20 patien...

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Main Authors: Wilson H Miller, Rahima Jamal, Karl Belanger, Khashayar Esfahani, Saman Maleki Vareki, Bertrand Routy, Seema Nair Parvathy, Arielle Elkrief, Michael S Silverman, Scott Ernst, Kelly J Baines, Danial Khan Hadi, Behnam Jabbarizadeh, Diane Logan, John Gordon Lenehan
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/8/e012659.full
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