PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have improved the prognosis of homologous recombination deficient (HRD) ovarian cancer (OC), while effective therapeutic strategies for HR-proficient (HRP) OC still need to be established. This study investigates senescence-mediated inflammatio...

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Bibliographic Details
Main Authors:	Misato Kamii, Ryo Kamata, Hitoshi Saito, Gaku Yamamoto, Chiaki Mashima, Toyohiro Yamauchi, Takehiro Nakao, Yuta Sakae, Tomoko Yamamori-Morita, Kazuki Nakai, Yumi Hakozaki, Masataka Takenaka, Aikou Okamoto, Akihiro Ohashi
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Series:	Scientific Reports
Subjects:	Poly (ADP-ribose) polymerase (PARP) inhibitors Homologous recombination-proficient (HRP) cancer Ovarian cancer (OC) Senescence-associated secretory phenotype (SASP)
Online Access:	https://doi.org/10.1038/s41598-025-00336-4
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