PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have improved the prognosis of homologous recombination deficient (HRD) ovarian cancer (OC), while effective therapeutic strategies for HR-proficient (HRP) OC still need to be established. This study investigates senescence-mediated inflammatio...

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Main Authors: Misato Kamii, Ryo Kamata, Hitoshi Saito, Gaku Yamamoto, Chiaki Mashima, Toyohiro Yamauchi, Takehiro Nakao, Yuta Sakae, Tomoko Yamamori-Morita, Kazuki Nakai, Yumi Hakozaki, Masataka Takenaka, Aikou Okamoto, Akihiro Ohashi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Poly (ADP-ribose) polymerase (PARP) inhibitors
Homologous recombination-proficient (HRP) cancer
Ovarian cancer (OC)
Senescence-associated secretory phenotype (SASP)
Online Access:https://doi.org/10.1038/s41598-025-00336-4
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https://doi.org/10.1038/s41598-025-00336-4

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