A Meta‐Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long‐Term Downregulation of Myelin‐Related Gene Expression

A Meta‐Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long‐Term Downregulation of Myelin‐Related Gene Expression

ABSTRACT Background Early life stress (ELS) refers to exposure to negative childhood experiences, such as neglect, disaster, and physical, mental, or emotional abuse. ELS can permanently alter the brain, leading to cognitive impairment, increased sensitivity to future stressors, and mental health ri...

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Main Authors: Toni Q. Duan, Megan H. Hagenauer, Elizabeth I. Flandreau, Anne Bader, Duy Manh Nguyen, Pamela M. Maras, Randriely Merscher S. De Lima, Trevonn Gyles, Christabel Mclain, Michael J. Meaney, Eric J. Nestler, Stanley J. Watson Jr., Huda Akil
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Brain and Behavior
Subjects:
early life stress
meta‐analysis
microarray
RNA‐Seq
Online Access:https://doi.org/10.1002/brb3.70608
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https://doi.org/10.1002/brb3.70608

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