Micro‐Scale Topography Triggers Dynamic 3D Nuclear Deformations

Micro‐Scale Topography Triggers Dynamic 3D Nuclear Deformations

Abstract Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole‐cell confinement that mimics the physical crowding experienced by cells during 3D migration through tissues. Such sys...

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Bibliographic Details
Main Authors: Claire Leclech, Giulia Cardillo, Bettina Roellinger, Xingjian Zhang, Joni Frederick, Kamel Mamchaoui, Catherine Coirault, Abdul I. Barakat
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
endothelial cells
laminopathies
microgrooves
myoblasts
nuclear deformations
nuclear mechanics
Online Access:https://doi.org/10.1002/advs.202410052
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https://doi.org/10.1002/advs.202410052

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