Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery
In this study, alginate-based composite beads were developed for the delivery of resveratrol, a compound with therapeutic potential. Two formulations were prepared: one with sodium alginate and resveratrol (AR) and another incorporating graphene nanoplatelets (AGR) to improve drug release control. T...
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2024-12-01
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| author | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Adina Stegarescu Septimiu Tripon Maria-Loredana Soran Ioana Bâldea |
| author_facet | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Adina Stegarescu Septimiu Tripon Maria-Loredana Soran Ioana Bâldea |
| author_sort | Cristina Mormile |
| collection | DOAJ |
| description | In this study, alginate-based composite beads were developed for the delivery of resveratrol, a compound with therapeutic potential. Two formulations were prepared: one with sodium alginate and resveratrol (AR) and another incorporating graphene nanoplatelets (AGR) to improve drug release control. The beads were formed by exploiting alginate’s ability to gel via ionic cross-linking. For the AGR formulation, sodium alginate was dissolved in water, and graphene was dispersed in isopropyl alcohol to achieve smaller flakes. Resveratrol was dissolved in an ethanol/water mixture and added to the graphene dispersion; the resulting solution was mixed with the alginate one. For the AR formulation, the resveratrol solution was mixed directly with the alginate solution. Both formulations were introduced into a calcium chloride solution to form the beads. The release of resveratrol was studied in phosphate-buffered saline at different pH values. Results showed that the presence of graphene in the AGR sample increased drug release, particularly at pH 6.8, indicating a pH-driven release mechanism. Kinetic analysis revealed that the Higuchi model best describes the release mechanism. Finally, cytotoxicity tests showed the biocompatibility of the system in normal human cells. These findings suggest that graphene-enhanced alginate matrices have significant potential for controlled drug delivery applications. |
| format | Article |
| id | doaj-art-8b6aced4f07d4e06aa25bb7aea0d6a08 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Gels |
| spelling | doaj-art-8b6aced4f07d4e06aa25bb7aea0d6a082025-01-24T13:33:46ZengMDPI AGGels2310-28612024-12-011111510.3390/gels11010015Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol DeliveryCristina Mormile0Ocsana Opriș1Stefano Bellucci2Ildiko Lung3Irina Kacso4Alexandru Turza5Adina Stegarescu6Septimiu Tripon7Maria-Loredana Soran8Ioana Bâldea9National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaR.A.I.T. 88 S.R.L, Via Pieve Torina 64/66, 00156 Rome, ItalyNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaDepartment of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, RomaniaIn this study, alginate-based composite beads were developed for the delivery of resveratrol, a compound with therapeutic potential. Two formulations were prepared: one with sodium alginate and resveratrol (AR) and another incorporating graphene nanoplatelets (AGR) to improve drug release control. The beads were formed by exploiting alginate’s ability to gel via ionic cross-linking. For the AGR formulation, sodium alginate was dissolved in water, and graphene was dispersed in isopropyl alcohol to achieve smaller flakes. Resveratrol was dissolved in an ethanol/water mixture and added to the graphene dispersion; the resulting solution was mixed with the alginate one. For the AR formulation, the resveratrol solution was mixed directly with the alginate solution. Both formulations were introduced into a calcium chloride solution to form the beads. The release of resveratrol was studied in phosphate-buffered saline at different pH values. Results showed that the presence of graphene in the AGR sample increased drug release, particularly at pH 6.8, indicating a pH-driven release mechanism. Kinetic analysis revealed that the Higuchi model best describes the release mechanism. Finally, cytotoxicity tests showed the biocompatibility of the system in normal human cells. These findings suggest that graphene-enhanced alginate matrices have significant potential for controlled drug delivery applications.https://www.mdpi.com/2310-2861/11/1/15drug deliverygrapheneresveratrolalginatekinetic analysis |
| spellingShingle | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Adina Stegarescu Septimiu Tripon Maria-Loredana Soran Ioana Bâldea Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery Gels drug delivery graphene resveratrol alginate kinetic analysis |
| title | Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery |
| title_full | Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery |
| title_fullStr | Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery |
| title_full_unstemmed | Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery |
| title_short | Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery |
| title_sort | natrium alginate and graphene nanoplatelets based efficient material for resveratrol delivery |
| topic | drug delivery graphene resveratrol alginate kinetic analysis |
| url | https://www.mdpi.com/2310-2861/11/1/15 |
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