UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

Abstract Dysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of intracellular C5aR1 expression for the infla...

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Main Authors: Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07862-z
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https://doi.org/10.1038/s41419-025-07862-z

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