Variations among glioblastoma cell lines in boron-mediated enhancement of cell killing by proton beams

Variations among glioblastoma cell lines in boron-mediated enhancement of cell killing by proton beams

Abstract Enhancement in cell killing by proton beams in the presence of boron (natural mixture natB: 80% 11B, 20% 10B) was reported, selectively in the Bragg peak region, putatively due to the proton-11B capture reaction. However, as some groups observed no such enhancement or assigned it to seconda...

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Main Authors: Oldřich Zahradníček, Pavel Kundrát, Irina Danilova, Pavel Bláha, Kateřina Pachnerová Brabcová, Anna Jelínek Michaelidesová, Jaroslav Šolc, Jana Vachelová, Matěj Navrátil, Vladimír Vondráček, Lucie Dyčková, Marie Davídková
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Proton-boron capture therapy
Glioblastoma cell lines
Cell survival
Proton beams
Secondary neutrons
Online Access:https://doi.org/10.1038/s41598-025-14658-w
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https://doi.org/10.1038/s41598-025-14658-w

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