Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation

Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation

Down syndrome (DS) is characterized by severe neurodevelopmental alterations that ultimately lead to the typical hallmark of DS: intellectual disability. In the DS brain, since the prenatal life stages, the number of astrocytes is disproportional compared to the healthy brain. This increase is due t...

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Bibliographic Details
Main Authors: Beatrice Uguagliati, Mariagrazia Grilli
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
astrocyte
down syndrome
neurodevelopment
neurogenesis
astrogliogenesis
synapses
Online Access:https://www.mdpi.com/2073-4409/13/24/2037
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https://www.mdpi.com/2073-4409/13/24/2037

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