C-X-C motif chemokine ligand 1 derived from oral squamous cell carcinoma promotes cancer-associated fibroblast differentiation and tumor growth

C-X-C motif chemokine ligand 1 derived from oral squamous cell carcinoma promotes cancer-associated fibroblast differentiation and tumor growth

Abstract Cancer-associated fibroblasts (CAFs), the predominant stromal cells in the tumor microenvironment (TME), play a critical role in the progression of solid tumors, including oral squamous cell carcinoma (OSCC). However, the molecular mechanisms by which OSCC-derived factors mediate CAF differ...

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Bibliographic Details
Main Authors: Soon Chul Heo, In-hye Nam, Bo Ram Keum, Yeo Gyun Yun, Jae-Yeol Lee, Hyung Joon Kim
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Molecular Biomedicine
Subjects:
Oral squamous cell carcinoma
Cancer-associated fibroblasts
C-X-C motif chemokine ligand 1
C-X-C motif chemokine receptor 2
Online Access:https://doi.org/10.1186/s43556-025-00281-8
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https://doi.org/10.1186/s43556-025-00281-8

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