A porcine model of acute rejection for cardiac transplantation

A porcine model of acute rejection for cardiac transplantation

Ex vivo machine perfusion has been growing in utility for preserving donor organs prior to transplantation. This modality has tremendous potential for bioengineering and conditioning organs prior to transplantation using small molecule or advanced therapeutics. To safely translate potential interven...

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Main Authors: Michelle Mendiola Pla, Yuting Chiang, Carolyn Glass, David C. Wendell, Devjanee Swain-Lenz, Sam Ho, Marat Fudim, Franklin H. Lee, Lillian Kang, Matthew F. Smith, Alejandro Alvarez Lobo, Kishen Mitra, Ryan T. Gross, Chunbo Wang, Muath Bishawi, Andrew Vekstein, Krish Dewan, JengWei Chen, Amy Evans, Antonio Roki, Paul Ferrell, Kristianne M. Oristian, Salvatore V. Pizzo, Jie Li, Laura P. Hale, Paul M. Lezberg, Carmelo A. Milano, Dawn E. Bowles
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
acute rejection
cardiac transplantation
machine perfusion
disease model
translational research
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1549377/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1549377/full

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