In silico exploration of anticancer plant phytochemicals for EGFR-targeted lung cancer therapy

In silico exploration of anticancer plant phytochemicals for EGFR-targeted lung cancer therapy

Abstract Mutations in the epidermal growth factor receptor (EGFR), particularly in the tyrosine kinase domain such as exon 19 deletions and the L858R point mutation, play a critical role in the development of non-small cell lung cancer (NSCLC). EGFR is a well-established therapeutic target in the ma...

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Main Authors: Chaity Debnath Dipa, Sharika Hossain, Md. Moinul Karim Chy, Mohammad Sheikh Farider Rahman, Tanvir Kayes, Afia Maimuna Easha, Abu Tayab Moin, Suvarna N. Vakare, Rajesh B. Patil, Bidduth Kumar Sarkar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Structure-based drug design
Epidermal growth factor receptor (EGFR)
Non-small cell lung cancer (NSCLC)
Molecular docking
Molecular dynamics simulation
Phytochemical screening
Online Access:https://doi.org/10.1038/s41598-025-10412-4
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https://doi.org/10.1038/s41598-025-10412-4

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