Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization

Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization

Abstract Lung cancer is the leading cause of cancer-related deaths globally. Prolonged targeted therapy use can lead to drug resistance and target mismatches, necessitating more effective and safer treatment strategies. Recent research has focused on the tumor microenvironment, which includes immune...

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Bibliographic Details
Main Authors: Yixin Zhou, Wenjin Teng, Jianchun Wu, Yingbin Luo, Yuli Wang, Yan Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biological Procedures Online
Subjects:
Lung cancer
Tumor-associated macrophages (TAMs)
M2 polarization
Endoplasmic reticulum stress (ERS)
Piperlongumine
Online Access:https://doi.org/10.1186/s12575-025-00279-0
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https://doi.org/10.1186/s12575-025-00279-0

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