Cancer Cell‐Derived Exosomal miR‐500a‐3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment

Cancer Cell‐Derived Exosomal miR‐500a‐3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment

Abstract Hepatocellular carcinoma (HCC) mainly depends on liver fibrosis/cirrhosis, which is regulated by tumor cells and the tumor microenvironment (TME), and is a crucial factor in tumor progression. This study aimed to identify abnormally expressed miR‐500a‐3p in the hepatitis‐cirrhosis‐HCC pathw...

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Bibliographic Details
Main Authors: Yu Zhang, Xin Li, Huiyan Chen, Jiawei Li, Xiaohuan Guo, Yilin Fang, Linjie Chen, Kaiqiang Li, Yi Zhang, Fei Kong, Aodong Chen, Jianxin Lyu, Wei Zhang, Zhen Wang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
exosome
hepatic stellate cell
hepatocellular carcinoma
T cell
tumor microenvironment
Online Access:https://doi.org/10.1002/advs.202404089
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