Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether atorvastatin treatment reduced the progression of a...

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Main Authors: Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu
Format: Article
Language:English
Published: BMJ Publishing Group 2019-12-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/6/1/e000333.full
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