Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays.

Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays.

Radiation sensitivity at low and high dose exposure to X-rays was investigated by means of chromosomal aberration (CA) analysis in heterozygous ATM mutation carrier and A-T patient (biallelic ATM mutation) lymphoblastoid cell lines (LCLs). Targeted and non-targeted responses to acutely delivered irr...

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Main Authors: Anne Kiuru, Meerit Kämäräinen, Sirpa Heinävaara, Katri Pylkäs, Kim Chapman, Armi Koivistoinen, Teuvo Parviainen, Robert Winqvist, Munira Kadhim, Virpi Launonen, Carita Lindholm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093211&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093211&type=printable

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