Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer

Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer

Oxylipins derived from dietary polyunsaturated fatty acids (PUFAs) are key determinants of intestinal health, homeostasis, and inflammatory disorders, such as colitis-associated colorectal cancer. Previous research has independently linked a high dietary omega (ω)-6:ω-3 PUFA ratio, or intestinal hel...

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Main Authors: Katherine A. Smith, Ella K. Reed, Irina Guschina, Victoria J. Tyrrell, Claire Butters, Matthew G. Darby, Brunette Katsandegwaza, Alisha Chetty, William G.C. Horsnell, Valerie B. O’Donnell, Awen Gallimore
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
cell signaling
colon
lipolysis and fatty acid metabolism
lipoxygenase
omega-3 fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000975
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