Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma

Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma

Purpose: Blocking of inhibitory receptors such as NK group-2 member-A (NKG2A) enhances tumor immunity of natural killer (NK) cells. Additionally, antibody-dependent cellular cytotoxicity (ADCC) is an important cytotoxic modality of action of NK cells, which act as a functional bridge between innate...

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Main Authors: Maryam Samareh-Salavatipour, Shirin Tavakoli, Maryam Barkhordar, Iman Seyhoun, Nasim Vousooghi, Mohammad Vaezi, Afshin Ghaderi, Tahereh Bakhtiari, Ardeshir Ghavamzadeh, Javad Verdi, Mohammad Ahmadvand
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2025-04-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
stomach neoplasms
natural killer cells
receptors
monalizumab
immune checkpoint proteins
cetuximab
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-15-143.pdf
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https://apb.tbzmed.ac.ir/PDF/apb-15-143.pdf

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