Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila.

Miro GTPases control mitochondrial morphology, calcium homeostasis, and regulate mitochondrial distribution by mediating their attachment to the kinesin and dynein motor complex. It is not clear, however, how Miro proteins spatially and temporally integrate their function as acute disruption of prot...

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Bibliographic Details
Main Authors: Francesca Mattedi, Ethlyn Lloyd-Morris, Frank Hirth, Alessio Vagnoni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002273
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