Development of a self-assembling multimeric Bann-RBD fusion protein in Pichia pastoris as a potential COVID-19 vaccine candidate

Development of a self-assembling multimeric Bann-RBD fusion protein in Pichia pastoris as a potential COVID-19 vaccine candidate

Abstract The development of an affordable and accessible vaccine platform is essential for achieving global and long-term protection against COVID-19 and other emerging viral diseases. In this study, we developed a multimeric fusion protein comprising the SARS-CoV-2 receptor-binding domain (RBD) and...

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Main Authors: Ozi Jumadila, Muhammad Dzul Fakhri, Adam Darsono, Fernita Puspasari, Sari Dewi Kurniasih, Fifi Fitriyah Masduki, Keni Vidilaseris, Ihsanawati Ihsanawati, Anita Artarini, Marselina Irasonia Tan, Ernawati Arifin Giri-Rachman, Dessy Natalia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
COVID-19
Multimeric protein
RBD
Subunit vaccine
β-annulus
Online Access:https://doi.org/10.1038/s41598-025-01242-5
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https://doi.org/10.1038/s41598-025-01242-5

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