DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.

DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques.

Previous studies of HIV-1 p55Gag immunization of mice have demonstrated the usefulness of targeting antigens to the cellular compartment containing the major histocompatibility complex type II (MHC II) complex molecules by use of a DNA antigen formulation encoding Gag as a chimera with the mouse lys...

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Bibliographic Details
Main Authors: Priya Chikhlikar, Luciana Barros de Arruda, Milton Maciel, Peter Silvera, Mark G Lewis, J Thomas August, Ernesto T A Marques
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000135&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000135&type=printable

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