BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer

BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer

Summary: In colon cancer, the BRAFV600E mutation is strongly associated with the CpG island methylator phenotype (CIMP). Here, we characterized the contribution of BRAFV600E to maintenance of aberrant DNA methylation using CRISPR-LbCpf1-corrected BRAF (V600E) organoids. DNA methylation analyses iden...

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Bibliographic Details
Main Authors: Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Molecular Genetics
Epigenetics
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011666
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http://www.sciencedirect.com/science/article/pii/S2589004225011666

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