Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection

Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection

Context Lipid nanoparticles (LNPs) are the primary non-viral vectors for siRNA delivery. However, synthetic lipids face issues, such as low lysosomal escape efficiency and high cost.Objective This study aimed to use three natural lipids to construct LNPs, optimize their preparation and freeze-drying...

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Bibliographic Details
Main Authors: Hangjie Wang, Wei Li, Junyan Chen, Rong Chen, Yuwei Qi, Linshuang Shen, Kaidi Chen, Lewei Dai, Yuxin Sheng, An Wang, Hong Wang, Chujian Chen, Xiao Cheng, Mancang Gu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Pharmaceutical Biology
Subjects:
Coix seed lipid
Brucea javanica seed lipid
soybean oil
endosomal escape
lipid droplet targeting
siRNA transfection
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2025.2498169
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https://www.tandfonline.com/doi/10.1080/13880209.2025.2498169

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