LAG3 as a marker of immune activation in esophageal squamous carcinoma treated with concurrent chemoradiotherapy

LAG3 as a marker of immune activation in esophageal squamous carcinoma treated with concurrent chemoradiotherapy

Abstract Introduction Esophageal squamous carcinoma (ESCC) is a common malignant tumor of the gastrointestinal tract with high morbidity and mortality rates. Lymphocyte activation gene-3 (LAG3), an important suppressive immune checkpoint in tumor immunity, exhibits a wobbling effect in the predictio...

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Main Authors: Yuxuan Zhang, Zijing Zhou, Yuanyuan Rui, Fanhao Kong, Zhoubo Guo, Gang Zhao, Jun Wang, Jiacheng Li, Fangdong Zhao, Hui Huang, Fang Fang, Jiarui Zhang, Tian Zhang, Wencheng Zhang, Ping Wang, Xi Chen, Peng Zhen, Qingsong Pang
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Esophageal squamous carcinoma
Concurrent radiotherapy
Immune checkpoint
Lymphocyte activation gene-3 (LAG3)
Online Access:https://doi.org/10.1007/s00262-025-04076-2
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https://doi.org/10.1007/s00262-025-04076-2

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