The natural statin α,β-dehydromonacolin K exerts anti-secretory effect in human intestinal epithelial cells via a nonsense-mediated mRNA decay-dependent mechanism

The natural statin α,β-dehydromonacolin K exerts anti-secretory effect in human intestinal epithelial cells via a nonsense-mediated mRNA decay-dependent mechanism

Context cAMP-induced intestinal chloride secretion plays a pivotal role in the pathogenesis of secretory diarrheas.Objective In this study, we investigated the antisecretory effects of α,β-dehydromonacolin K, a derivative of lovastatin from Aspergillus sclerotiorum, on cAMP-induced chloride secretio...

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Bibliographic Details
Main Authors: Saravut Satitsri, Rungtiwa Khumjiang, Chittreeya Tansakul, Wararat Chiangjong, Nuttapon Apichaiyarat, Taya Kitiyakara, Yanisa Purintrapibal, Vatcharin Rukachaisirikul, Chatchai Muanprasat
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Pharmaceutical Biology
Subjects:
α,β-Dehydromonacolin K
diarrhea
CFTR
human colonoid
NMD
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2025.2544930
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https://www.tandfonline.com/doi/10.1080/13880209.2025.2544930

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