Modeling the use of transient ligand binding information by AMPA receptors

Abstract Glutamate mediates fast excitatory neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors in the central nervous system. Although it is well known that the glutamate affinity for AMPA receptors is submicromolar, ligand-dependent curre...

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Bibliographic Details
Main Authors: Helena Braunstein, Alejandra C. Ventura, Alejandro Colman-Lerner
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00546-6
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