Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review
“Lipomatous” and “extensively vacuolated” are descriptive captions that have been used to portray a curious subset of ependymomas distinctively bearing cells with a large vacuole pushing the nucleus to the periphery and, thus, simulating a signet-ring cell appearance. Here, we would like to report t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2017/8617050 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561780161773568 |
|---|---|
| author | Miguel Fdo. Salazar Martha Lilia Tena-Suck Alma Ortiz-Plata Citlaltepetl Salinas-Lara Daniel Rembao-Bojórquez |
| author_facet | Miguel Fdo. Salazar Martha Lilia Tena-Suck Alma Ortiz-Plata Citlaltepetl Salinas-Lara Daniel Rembao-Bojórquez |
| author_sort | Miguel Fdo. Salazar |
| collection | DOAJ |
| description | “Lipomatous” and “extensively vacuolated” are descriptive captions that have been used to portray a curious subset of ependymomas distinctively bearing cells with a large vacuole pushing the nucleus to the periphery and, thus, simulating a signet-ring cell appearance. Here, we would like to report the first ependymoma of this kind in a Latin American institution. A 16-year-old boy experienced cephalea during three months. Magnetic resonance imaging scans showed a left paraventricular tumour which corresponded to anaplastic ependymoma. Intriguingly, it was also composed of cells with single or multiple hollow cytoplasmic vacuoles sometimes giving a signet-ring cell-like configuration. Immunolabeling of these showed membrane positivity for GFAP, PS100, and CD99, while Ki-67 expression was null. Ultrastructural examination of retrieved paraffin-embedded tissue showed the presence of scarce microlumina filled with microvilli but failed to demonstrate any content in such optically empty vacuoles as only scant granulofibrillary debris was observed. A schism prevails at present regarding these unusual morphological variants, being either “lipomatous” or “vacuolated” based mainly on the EMA immunoprofile. This, however, is a misappropriate approaching. Could it be that perhaps we are dealing with the same histopathological entity or it may simply happen that fixation and artefacts cannot allow for their proper identification? |
| format | Article |
| id | doaj-art-8ab6a9b8329c462a8428eccb44e206a7 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-8ab6a9b8329c462a8428eccb44e206a72025-02-03T01:24:16ZengWileyCase Reports in Pathology2090-67812090-679X2017-01-01201710.1155/2017/86170508617050Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature ReviewMiguel Fdo. Salazar0Martha Lilia Tena-Suck1Alma Ortiz-Plata2Citlaltepetl Salinas-Lara3Daniel Rembao-Bojórquez4Department of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, Mexico City, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, Mexico City, MexicoLaboratory of Experimental Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, Mexico City, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, Mexico City, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, Mexico City, Mexico“Lipomatous” and “extensively vacuolated” are descriptive captions that have been used to portray a curious subset of ependymomas distinctively bearing cells with a large vacuole pushing the nucleus to the periphery and, thus, simulating a signet-ring cell appearance. Here, we would like to report the first ependymoma of this kind in a Latin American institution. A 16-year-old boy experienced cephalea during three months. Magnetic resonance imaging scans showed a left paraventricular tumour which corresponded to anaplastic ependymoma. Intriguingly, it was also composed of cells with single or multiple hollow cytoplasmic vacuoles sometimes giving a signet-ring cell-like configuration. Immunolabeling of these showed membrane positivity for GFAP, PS100, and CD99, while Ki-67 expression was null. Ultrastructural examination of retrieved paraffin-embedded tissue showed the presence of scarce microlumina filled with microvilli but failed to demonstrate any content in such optically empty vacuoles as only scant granulofibrillary debris was observed. A schism prevails at present regarding these unusual morphological variants, being either “lipomatous” or “vacuolated” based mainly on the EMA immunoprofile. This, however, is a misappropriate approaching. Could it be that perhaps we are dealing with the same histopathological entity or it may simply happen that fixation and artefacts cannot allow for their proper identification?http://dx.doi.org/10.1155/2017/8617050 |
| spellingShingle | Miguel Fdo. Salazar Martha Lilia Tena-Suck Alma Ortiz-Plata Citlaltepetl Salinas-Lara Daniel Rembao-Bojórquez Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review Case Reports in Pathology |
| title | Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review |
| title_full | Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review |
| title_fullStr | Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review |
| title_full_unstemmed | Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review |
| title_short | Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review |
| title_sort | lipomatous extensively vacuolated ependymoma with signet ring cell like appearance analysis of a case with extensive literature review |
| url | http://dx.doi.org/10.1155/2017/8617050 |
| work_keys_str_mv | AT miguelfdosalazar lipomatousextensivelyvacuolatedependymomawithsignetringcelllikeappearanceanalysisofacasewithextensiveliteraturereview AT marthaliliatenasuck lipomatousextensivelyvacuolatedependymomawithsignetringcelllikeappearanceanalysisofacasewithextensiveliteraturereview AT almaortizplata lipomatousextensivelyvacuolatedependymomawithsignetringcelllikeappearanceanalysisofacasewithextensiveliteraturereview AT citlaltepetlsalinaslara lipomatousextensivelyvacuolatedependymomawithsignetringcelllikeappearanceanalysisofacasewithextensiveliteraturereview AT danielrembaobojorquez lipomatousextensivelyvacuolatedependymomawithsignetringcelllikeappearanceanalysisofacasewithextensiveliteraturereview |