annATAC: automatic cell type annotation for scATAC-seq data based on language model

annATAC: automatic cell type annotation for scATAC-seq data based on language model

Abstract Background Cell type annotation serves as the cornerstone for downstream analysis of single cell data. Nevertheless, scATAC-seq data is characterized by high sparsity and dimensionality, presenting significant challenges to its annotation process. Results We introduce a novel method based o...

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Bibliographic Details
Main Authors: Lingyu Cui, Fang Wang, Hongfei Li, Qiaoming Liu, Murong Zhou, Guohua Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
Single cell epigenomics
Automatic annotation
Language model
Pre-training
Fine-tuning
Online Access:https://doi.org/10.1186/s12915-025-02244-5
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https://doi.org/10.1186/s12915-025-02244-5

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