Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates

Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates

Abstract Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mH...

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Main Authors: Jordy Akkermans, Alan Miranda, Jeroen Verhaeghe, Filipe Elvas, Franziska Zajicek, Jonathan Bard, Longbin Liu, Vinod Khetarpal, Robert Doot, Steven Staelens, Daniele Bertoglio
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Research
Subjects:
Huntington’s disease
Positron emission tomography
In vivo dosimetry
Ex vivo dosimetry
Mouse
Online Access:https://doi.org/10.1186/s13550-024-01188-1
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https://doi.org/10.1186/s13550-024-01188-1

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