Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment

Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment

The potassium sodium-activated channel subtype T member 1 (<i>KCNT1</i>) gene encodes the Slack channel K<sub>Na</sub>1.1, which is expressed in neurons throughout the brain. Gain-of-function variants in <i>KCNT1</i> are associated with a spectrum of epilepsy synd...

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Bibliographic Details
Main Authors: Fangxu Sun, Huafeng Wang, Jing Wu, Imran H. Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A. Jonas, Viet Nguyen, Sijia Wu, Omar S. Mabrouk, Paymaan Jafar-nejad, Leonard K. Kaczmarek
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
slack
KCNT1
K<sub>Na</sub>1.1
epilepsy
intellectual disability
EIMFS
Online Access:https://www.mdpi.com/2218-273X/14/11/1397
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