ALKBH5 modulates m6A modification to enhance acute myeloid leukemia resistance to adriamycin

ALKBH5 modulates m6A modification to enhance acute myeloid leukemia resistance to adriamycin

Acute myeloid leukemia (AML) is a fatal malignancy with rising incidence and low cure rates. This study aims to investigate the effect of ALKBH5-mediated m6A modification on adriamycin (ADR) resistance in AML. First, the levels of ALKBH5, TUG1, YTHDF2, EHMT2, and SH3BGRL were measured. IC50 values,...

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Bibliographic Details
Main Authors: Yonghua Liu, Jinhong Jiang, Yuxiao Zeng, Yu Jiang
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2024-10-01
Series:Biomolecules & Biomedicine
Subjects:
ALKBH5
TUG1
SH3BGRL
EHMT2
acute myeloid leukemia
N6-methyladenosine
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/11076
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