Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies
In this contribution we present three case studies of physiologically based toxicokinetic (PBTK) modelling in regulatory risk assessment. (1) Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA) blood levels which are near the levels of the tolerated daily intake (TDI) at...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/359471 |
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| author | Hans Mielke Ursula Gundert-Remy |
| author_facet | Hans Mielke Ursula Gundert-Remy |
| author_sort | Hans Mielke |
| collection | DOAJ |
| description | In this contribution we present three case studies of physiologically based toxicokinetic (PBTK) modelling in regulatory risk assessment. (1) Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA) blood levels which are near the levels of the tolerated daily intake (TDI) at the oral exposure as calculated by EFSA. (2) Dermal exposure of BPA by receipts, car park tickets, and so forth, contribute to the exposure towards BPA. However, at the present levels of dermal exposure there is no risk for the adult. (3) Dermal exposure towards coumarin via cosmetic products leads to external exposures of two-fold the TDI. PBTK modeling helped to identify liver peak concentration as the metric for liver toxicity. After dermal exposure of twice the TDI, the liver peak concentration was lower than that present after oral exposure with the TDI dose. In the presented cases, PBTK modeling was useful to reach scientifically sound regulatory decisions. |
| format | Article |
| id | doaj-art-8a85cfb2105540998282f5a820485c8f |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-8a85cfb2105540998282f5a820485c8f2025-08-20T02:09:18ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/359471359471Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case StudiesHans Mielke0Ursula Gundert-Remy1Federal Institute for Risk Assessment, Max Dohrn Strasse 8-10, 10589 Berlin, GermanyFederal Institute for Risk Assessment, Max Dohrn Strasse 8-10, 10589 Berlin, GermanyIn this contribution we present three case studies of physiologically based toxicokinetic (PBTK) modelling in regulatory risk assessment. (1) Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA) blood levels which are near the levels of the tolerated daily intake (TDI) at the oral exposure as calculated by EFSA. (2) Dermal exposure of BPA by receipts, car park tickets, and so forth, contribute to the exposure towards BPA. However, at the present levels of dermal exposure there is no risk for the adult. (3) Dermal exposure towards coumarin via cosmetic products leads to external exposures of two-fold the TDI. PBTK modeling helped to identify liver peak concentration as the metric for liver toxicity. After dermal exposure of twice the TDI, the liver peak concentration was lower than that present after oral exposure with the TDI dose. In the presented cases, PBTK modeling was useful to reach scientifically sound regulatory decisions.http://dx.doi.org/10.1155/2012/359471 |
| spellingShingle | Hans Mielke Ursula Gundert-Remy Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies Journal of Toxicology |
| title | Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies |
| title_full | Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies |
| title_fullStr | Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies |
| title_full_unstemmed | Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies |
| title_short | Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies |
| title_sort | physiologically based toxicokinetic modelling as a tool to support risk assessment three case studies |
| url | http://dx.doi.org/10.1155/2012/359471 |
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