Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

IntroductionOsteosarcoma (OS) is the most common primary malignant bone tumor in pediatric populations. Its treatment is complicated by chemotherapy-induced toxicity and limited induction of immunogenic cell death (ICD).MethodsTo address these challenges, we developed a pH-responsive, multi-componen...

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Bibliographic Details
Main Authors: Dapeng Li, Yuanfan Li, Jie Cang, Xianwen Yan, Feipeng Wu, Xuan Sun, Wenchao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
osteosarcoma
pH-responsive immune-modulating nanoparticles
tumor microenvironment reprogramming
immunogenic cell death
TLR4 and STING agonists
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1584245/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1584245/full

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