Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice

Abstract Dual inhibition of sodium glucose cotransporters 1 and 2 (SGLT1/SGLT2) by sotagliflozin protects the kidney and heart in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). To gain mechanistic insights, the current study aimed to establish a murine model of hyper...

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Bibliographic Details
Main Authors: Helen Goodluck, Alice Zemljic‐Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70217
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