ProT‐Diff: A Modularized and Efficient Strategy for De Novo Generation of Antimicrobial Peptide Sequences by Integrating Protein Language and Diffusion Models

ProT‐Diff: A Modularized and Efficient Strategy for De Novo Generation of Antimicrobial Peptide Sequences by Integrating Protein Language and Diffusion Models

Abstract Antimicrobial peptides (AMPs) are a promising solution for treating antibiotic‐resistant pathogens. However, efficient generation of diverse AMPs without prior knowledge of peptide structures or sequence alignments remains a challenge. Here, ProT‐Diff is introduced, a modularized deep gener...

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Bibliographic Details
Main Authors: Xue‐Fei Wang, Jing‐Ya Tang, Jing Sun, Sonam Dorje, Tian‐Qi Sun, Bo Peng, Xu‐Wo Ji, Zhe Li, Xian‐En Zhang, Dian‐Bing Wang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
antimicrobial peptide
artificial intelligent
de novo design
diffusion model
protein language model
Online Access:https://doi.org/10.1002/advs.202406305
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https://doi.org/10.1002/advs.202406305

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