The dimeric conformation of PRRSV nsp1α is important for its ability to regulate viral RNA synthesis

The dimeric conformation of PRRSV nsp1α is important for its ability to regulate viral RNA synthesis

Abstract PRRSV nsp1α, the first viral protein translated in virus-infected cells, is released from viral polyprotein 1a through autocleavage. It plays important roles in viral replication, the suppression of the host innate immune response, and the modulation of cell-mediated immune responses. Nsp1α...

Full description

Saved in:
Bibliographic Details
Main Authors: Qingyu Li, Jingbo Hu, Xue Jiao, Jing Shi, Chenxi Li, Yanhua Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Veterinary Research
Subjects:
PRRSV
nsp1α dimerization
viral RNA synthesis
subgenomic RNA
transcriptional regulation
Online Access:https://doi.org/10.1186/s13567-025-01537-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13567-025-01537-5

Similar Items