A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Abstract Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large‐scale sequencing efforts. Using genome‐scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and c...

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Main Authors: Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O'Brien, Brenda Andrews, Charles Boone, Jason Moffat
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:Molecular Systems Biology
Subjects:
genetic interaction
genome stability
mitotic stress
pooled shRNA screening
Online Access:https://doi.org/10.1038/msb.2013.54
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https://doi.org/10.1038/msb.2013.54

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