Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling

Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling

<b>Objectives:</b> Metabolic dysfunction-associated steatohepatitis (MASH) lacks effective therapies. This study aimed to evaluate the therapeutic potential of compound <b>3d</b>, a novel elafibranor derivative, focusing on its dual mechanisms of PPAR pathway activation and p...

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Main Authors: Shouqing Zhang, Jiajia Yu, Sule Bai, Shuhan Li, Quanyuan Qiu, Xiangshun Kong, Cen Xiang, Zhen Liu, Peng Yu, Yuou Teng
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Metabolites
Subjects:
elafibranor derivative
MASH
PPAR pathway activation
p38 MAPK signaling inhibition
gut microbiota modulation
Online Access:https://www.mdpi.com/2218-1989/15/5/296
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