Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Abstract Targeting RNA-dependent RNA polymerase (RdRp), a highly conserved enzyme essential for SARS coronavirus 2 (SARS-CoV-2) replication and transcription, represents a promising antiviral strategy due to its lower mutation rate than structural proteins such as Spike. This study introduces a cell...

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Bibliographic Details
Main Authors: Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
RdRp
High-throughput screening
Cell-based reporter assay
SARS-CoV-2 RdRp inhibitor
Online Access:https://doi.org/10.1038/s41598-025-03813-y
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https://doi.org/10.1038/s41598-025-03813-y

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