Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids

ABSTRACT Despite their relatedness, Salmonella and Shigella enteropathogens differ in infectious dose, pathogenesis, and disease kinetics. The prototype strains Salmonella enterica serovar Typhimurium (Salmonella) and Shigella flexneri (Shigella) use Type-3-secretion-systems (T3SSs) to colonize inte...

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Main Authors: Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Salmonella
Shigella
enteroids
colonoids
invasion
inflammasome
Online Access:https://journals.asm.org/doi/10.1128/mbio.00911-25
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https://journals.asm.org/doi/10.1128/mbio.00911-25

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