A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

Abstract Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we developed a cell‐permeable, high‐affinity (~2 nM) pep...

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Main Authors: Nikolaj R Christensen, Marta De Luca, Michael B Lever, Mette Richner, Astrid B Hansen, Gith Noes‐Holt, Kathrine L Jensen, Mette Rathje, Dennis Bo Jensen, Simon Erlendsson, Christian RO Bartling, Ina Ammendrup‐Johnsen, Sofie E Pedersen, Michèle Schönauer, Klaus B Nissen, Søren R Midtgaard, Kaare Teilum, Lise Arleth, Andreas T Sørensen, Anders Bach, Kristian Strømgaard, Claire F Meehan, Christian B Vægter, Ulrik Gether, Kenneth L Madsen
Format: Article
Language:English
Published: Springer Nature 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
biopharmaceuticals
calcium permeable AMPARs
maladaptive plasticity
scaffold proteins
synaptic plasticity
Online Access:https://doi.org/10.15252/emmm.201911248
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https://doi.org/10.15252/emmm.201911248

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