Erythropoietin couples hematopoiesis with bone formation.
<h4>Background</h4>It is well established that bleeding activates the hematopoietic system to regenerate the loss of mature blood elements. We have shown that hematopoietic stem cells (HSCs) isolated from animals challenged with an acute bleed regulate osteoblast differentiation from mar...
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Public Library of Science (PLoS)
2010-05-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010853&type=printable |
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| author | Yusuke Shiozawa Younghun Jung Anne M Ziegler Elisabeth A Pedersen Jianhua Wang Zhuo Wang Junhui Song Jingcheng Wang Clara H Lee Sudha Sud Kenneth J Pienta Paul H Krebsbach Russell S Taichman |
| author_facet | Yusuke Shiozawa Younghun Jung Anne M Ziegler Elisabeth A Pedersen Jianhua Wang Zhuo Wang Junhui Song Jingcheng Wang Clara H Lee Sudha Sud Kenneth J Pienta Paul H Krebsbach Russell S Taichman |
| author_sort | Yusuke Shiozawa |
| collection | DOAJ |
| description | <h4>Background</h4>It is well established that bleeding activates the hematopoietic system to regenerate the loss of mature blood elements. We have shown that hematopoietic stem cells (HSCs) isolated from animals challenged with an acute bleed regulate osteoblast differentiation from marrow stromal cells. This suggests that HSCs participate in bone formation where the molecular basis for this activity is the production of BMP2 and BMP6 by HSCs. Yet, what stimulates HSCs to produce BMPs is unclear.<h4>Methodology/principal findings</h4>In this study, we demonstrate that erythropoietin (Epo) activates Jak-Stat signaling pathways in HSCs which leads to the production of BMPs. Critically, Epo also directly activates mesenchymal cells to form osteoblasts in vitro, which in vivo leads to bone formation. Importantly, Epo first activates osteoclastogenesis which is later followed by osteoblastogenesis that is induced by either Epo directly or the expression of BMPs by HSCs to form bone.<h4>Conclusions/significance</h4>These data for the first time demonstrate that Epo regulates the formation of bone by both direct and indirect pathways, and further demonstrates the exquisite coupling between hematopoiesis and osteopoiesis in the marrow. |
| format | Article |
| id | doaj-art-8a130f813fb94deaa1d3cd0f1c917bc4 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-8a130f813fb94deaa1d3cd0f1c917bc42025-08-20T03:07:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-05-0155e1085310.1371/journal.pone.0010853Erythropoietin couples hematopoiesis with bone formation.Yusuke ShiozawaYounghun JungAnne M ZieglerElisabeth A PedersenJianhua WangZhuo WangJunhui SongJingcheng WangClara H LeeSudha SudKenneth J PientaPaul H KrebsbachRussell S Taichman<h4>Background</h4>It is well established that bleeding activates the hematopoietic system to regenerate the loss of mature blood elements. We have shown that hematopoietic stem cells (HSCs) isolated from animals challenged with an acute bleed regulate osteoblast differentiation from marrow stromal cells. This suggests that HSCs participate in bone formation where the molecular basis for this activity is the production of BMP2 and BMP6 by HSCs. Yet, what stimulates HSCs to produce BMPs is unclear.<h4>Methodology/principal findings</h4>In this study, we demonstrate that erythropoietin (Epo) activates Jak-Stat signaling pathways in HSCs which leads to the production of BMPs. Critically, Epo also directly activates mesenchymal cells to form osteoblasts in vitro, which in vivo leads to bone formation. Importantly, Epo first activates osteoclastogenesis which is later followed by osteoblastogenesis that is induced by either Epo directly or the expression of BMPs by HSCs to form bone.<h4>Conclusions/significance</h4>These data for the first time demonstrate that Epo regulates the formation of bone by both direct and indirect pathways, and further demonstrates the exquisite coupling between hematopoiesis and osteopoiesis in the marrow.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010853&type=printable |
| spellingShingle | Yusuke Shiozawa Younghun Jung Anne M Ziegler Elisabeth A Pedersen Jianhua Wang Zhuo Wang Junhui Song Jingcheng Wang Clara H Lee Sudha Sud Kenneth J Pienta Paul H Krebsbach Russell S Taichman Erythropoietin couples hematopoiesis with bone formation. PLoS ONE |
| title | Erythropoietin couples hematopoiesis with bone formation. |
| title_full | Erythropoietin couples hematopoiesis with bone formation. |
| title_fullStr | Erythropoietin couples hematopoiesis with bone formation. |
| title_full_unstemmed | Erythropoietin couples hematopoiesis with bone formation. |
| title_short | Erythropoietin couples hematopoiesis with bone formation. |
| title_sort | erythropoietin couples hematopoiesis with bone formation |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010853&type=printable |
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